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ALC was generally well tolerated, with predominantly mild gastrointestinal or central nervous system adverse events and no excess of serious harms compared with controls

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In addition, the expression levels of several genes associated with apoptosis were upregulated in the adipocyte-rich fraction isolated from eWAT or sWAT of intermittently fasted (HFD-IF) in comparison to ad libitum fed (HFD-AL) obese mice, while markers of senescence ( p16 ) and DNA-damage ( Parp1 ) were not changed (Fig